Is there such a factor as an excessive amount of?
Protein is an important macronutrient for muscle progress. (1) It helps restore and create new cells to construct muscle. However how a lot protein is important to optimize muscle progress? Does elevated protein consumption result in higher good points, or can extreme protein consumption have undesirable unintended effects?
Dr. Tom Trommelen, a researcher specializing in protein metabolism at Maastricht College within the Netherlands, and PhD of sports activities science Dr. Milo Wolf from Stronger By Science addressed these questions on Oct. 13, 2024. Study what occurs to the consumption of extra protein beneath:
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The Idea of Protein Synthesis
Dr. Wolf explains that protein digestion takes place in 4 steps:
- The digestion course of begins with the tooth. They carry out mechanical digestion, which is breaking down meals into smaller particles, growing the floor space for enzymes to behave upon.
- Meals strikes via the digestive tract into the abdomen, the place gastric glands secrete hydrochloric acid (HCl) to interrupt protein bonds into smaller peptide fragments.
- Meals enters the small gut, the place the partitions take in amino acids and launch them into the bloodstream.
- These amino acids journey all through the physique through the blood, offering varied tissues with the required elements for protein synthesis or to be oxidized for power.
Varied tissues all through the physique, not simply muscle tissues, can make the most of amino acids for protein synthesis.
Your muscle has a reasonably low protein turnover fee in comparison with different tissues, like hair.
—Dr. Milo Wolf
Dr. Wolf describes how protein may be oxidized or burned for power via deamination, which happens within the liver and includes the elimination of the amino group. This course of produces keto acids, which the physique then makes use of to transform proteins into glucose, in the end using this finish product for power.
Protein Ingestion
Dr. Trommelen references earlier research, together with one indicating that the preliminary 20 grams of protein elicits a linear anabolic response, adopted by a further profit from the following 20 grams, totaling 40 grams. Additional protein consumption diminishes returns, as extra protein is both burned off or oxidized. Nevertheless, latest analysis involving contributors consuming 25 grams and 100 grams of protein challenges this notion.

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In response to Dr. Wolf, the examine’s findings reveal that consuming between 25 grams and 100 grams of protein doesn’t considerably enhance protein oxidation. (2) The degrees of amino acids transported from the bloodstream to tissues had been notably increased when contributors ingested 100 grams than 25 grams. However what occurs to the excess protein?
- 0-4 hours: The 100-gram group exhibited a 20% enhance in protein synthesis in comparison with the 25-gram group.
- 4-12 hours: The 100-gram group confirmed a 40% enhance in protein synthesis over the 25-gram group.
- The discharge of amino acids into the bloodstream for these consuming 100 grams didn’t stop after 12 hours, whereas for many who ingested 25 grams, the discharge stopped across the four-hour mark.
These findings counsel that people consuming 100 grams of protein in a single sitting aren’t losing protein. (3)
Dr. Trommelen famous that earlier research concerned contributors consuming a single meal whereas measuring the anabolic response over 4 to 5 hours. Nevertheless, when people eat a considerable quantity of protein, they require further time to digest it successfully.
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Protein Consumption Suggestions
Dr. Trommelen recommends that athletes intention for 4 meals every day, encompassing breakfast, lunch, dinner, and a further meal earlier than mattress. Breaking apart meals all through the day quite than digesting an excessive amount of in a single meal aids protein distribution.
Dr. Wolf additional emphasizes this technique can extra successfully guarantee ample whole protein consumption for the physique.
Extra Diet Content material
References
- Carbone, J. W., & Pasiakos, S. M. (2019). Dietary Protein and Muscle Mass: Translating Science to Software and Well being Profit. Vitamins, 11(5), 1136. https://doi.org/10.3390/nu11051136
- Schoenfeld, B. J., & Aragon, A. A. (2018). How a lot protein can the physique use in a single meal for muscle-building? Implications for every day protein distribution. Journal of the Worldwide Society of Sports activities Diet, 15, 10. https://doi.org/10.1186/s12970-018-0215-1
- Trommelen, J., van Lieshout, G. A. A., Nyakayiru, J., Holwerda, A. M., Smeets, J. S. J., Hendriks, F. Ok., van Kranenburg, J. M. X., Zorenc, A. H., Senden, J. M., Goessens, J. P. B., Gijsen, A. P., & van Loon, L. J. C. (2023). The anabolic response to protein ingestion throughout restoration from train has no higher restrict in magnitude and period in vivo in people. Cell reviews. Medication, 4(12), 101324. https://doi.org/10.1016/j.xcrm.2023.101324
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